Program Name: Biomedical Sciences
Course Name: New Advances on Validated Drug Target Families Course Id: 2111
Module 1 teaches the principles of discovery of biological targets and active compounds by hypothesis-driven and high-throughput approaches with both experimental and computational methods. This is followed by characterization of biological target interactions with lead compounds (i.e., structure, energy and dynamics). The inferred molecular mechanisms provide the basis for lead optimization through rational design and medicinal chemistry, and drug candidate selection through evaluation of drug toxicity and effacacy, as well as drug pharmacokinetics/pharmacodynamics properties. Modules 2 and 3review the latest adancements in drug discovery for both valdiated and emerging drug target familities consisting of proteins involved in enzymatic catalysis, gene transcription and translation, protein-protein or protein-nucleic acid interactions.
Semester Offered: Spring
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