Name: Mac Leod, Jesica
Year you started at ISMMS: 2010
Lab: Adolfo Garcia-Sastre
Lab Mailing Address:
One Gustave L Levy Place, Box 1234
New York, NY 10029
Study the mechanisms that regulate virus-host interactions of RNA viruses as well as possible antiviral drugs. Developing the biochemical study of viral proteins that have a negative effect in the human immune system, as well as the development of inhibitors for these proteins. This work has resulted in collaboration and one publication in Proceedings of National Academy of Sciences (PNAS). This work will make a significant contribution to the field because it may constitute the first of this kind research comparing viral with mammalians proteins in order to understand the differences, aiming the development of specific inhibitors for the viral proteins.
Also we co authored the Chapter: Nairovirus deubiquitinylating peptidase, included in the Handbook of proteolytic enzymes in 2013, published by Elseiver.
Her studies on the mapping of the nucleoprotein of Crimean-Congo hemorrhagic fever virus (CCHFV), have been published in the Journal of General Virology. These results may guide the development of potent inhibitors of these complexes that could potentially block CCHFV replication.
Previous Postdoc Experience:
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